The origins of Tau Kappa Epsilon began in October 28th 1966 when a small group of college men at Morehead State University created a local university club, Zeta Alpha Phi. Due to the character of the men involved ZAP quickly became one of the leading fraternal organizations on campus. In 1968 discussions began for ZAP to join TKE, a leading national fraternity. This goal was achieved when the Zeta Alpha Phi university club of Morehead State University pledged themselves to Tau Kapp Epsilon fraternity in an initiation ceremony held at St. Albans Church on February 18th 1969. This event created the first national fraternity at MSU.

In the ensuing decades TKE continued to provide leadership and an example of excellent on the Morehead State University campus. The Mu Sigma chapter of Tau Kappa Epsilon at Morehead State University for over 50 years has fostered leadership development and fraternal bonds of brotherhood between active and alumni across all generations. TKE at MSU is a fraternity for life.

• Two buildings and one room on campus bear the name of TKE MSU alumni. The Adron Doran University Center (ADUC) is named after TKE alumni and former legendary MSU President Dr. Adron Doran. The Elmer Smith College of Business and Technology is named after TKE alumni and past fraternity president Elmer Smith. The cheer room at AAC was named after TKE Alumni and long-time fraternity advisor Myron Doan.
• Brian Shimer, a TKE MSU alumni earned an Olympic medal in bobsled.
• Phil Simms, a TKE MSU alumni was selected as MVP of a Superbowl.
• Mike Fox and Steve Strathmann, both active TKE members were the student body President at MSU.
• More than once, a TKE little sister has been the MSU Homecoming Queen.
• The fraternity once owned two cannons and one chariot!
• The founding brothers of TKE persuaded a sitting MSU President to join the fraternity.
• Fraternity members once washed airplanes for a fundraiser.
• There is a TKE room in the newly renovated ADUC made possible by a $50,000 donation to the university by TKE alumni.